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Mechanism of Metallothionein Gene Activation Mediated by Heavy-Metal Dependent Transcription Factor MTF-1

✍ Scribed by Fuminori Otsuka; Shotaro Ohno; Kaoru Suzuki; Kazuko Takahashi; Motoyasu Ohsawa; Shinji Koizumi

Publisher: John Wiley and Sons
Year: 2007
Weight: 11 KB
Volume: 38
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200733269

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✦ Synopsis

Abstract

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Induction of metallothioneins (MTs) through the metal-activated transcription factor-1 (MTF-1) provides a model response for analyzing transcriptional gene regulation by heavy metals. Here, we report inhibition of protein synthesis by cycloheximide (CHX) increases induction of Mt1 by approximately f