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Mechanism of Lysophosphatidylcholine-Induced Lysosome Destabilization

✍ Scribed by Jin-Shan Hu; Ying-Bin Li; Jiong-Wei Wang; Lin Sun; Guo-Jiang Zhang

Book ID
105926570
Publisher
Springer
Year
2007
Tongue
English
Weight
240 KB
Volume
215
Category
Article
ISSN
0022-2631

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Lob concentrations of some neutral dipeptides, such as L-Ala-L-Ala, rapidly disrupt rat liver lysosomes. The phenomenon has been attributed to an osmotic imbalance generated by the production of amino acids in the lysosome by lysosomal dipeptidase activity. This hypothesis is challenged by testing s