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Mechanism of lithium-induced polyuria in the rat

✍ Scribed by Carney, Shane L; Ray, Cheryl; Gillies, Alastair HB

Book ID
109884511
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
651 KB
Volume
50
Category
Article
ISSN
0085-2538

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✍ Y. Bersudsky; I. Vinnitsky; N. Grisaru; U. Yaroslavsky; S. Gheorghiu; D. Ivgi; O πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 395 KB

It has been proposed that lithium acts by inhibiting inositol monophosphatase, thereby lowering tissue inositol levels. We therefore studied inositol effects on a prominent lithium side-effect, polyuria-polydipsia, in rats and in humans. Rats were treated with daily injections i.p. LiCl for 14 days