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Mechanism of L-arginine-induced insulin release from the rat pancreas

✍ Scribed by I. Shimoda; J. Ishizuka; K. Sato; T. Tsuchiya; C.M. Townsend Jr.; J.C. Thompson


Book ID
118399563
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
86 KB
Volume
40
Category
Article
ISSN
0167-0115

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The isolated perfused rat pancreas was stimulated sequentially with arginine or glucose to analyze the time-dependent modulation of insulin release. A 10-min perfusion with arginine (5.0 mmol/l) induced 75% inhibition of the insulin response to repeated arginine stimulation 10 min later. When glucos