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Mechanism of inhibition of phosphoribosylation of 5-fluorouracil by purines

✍ Scribed by Mitsuzi Yoshida; Akio Hoshi

Book ID: 115777494
Publisher: Elsevier Science
Year: 1984
Tongue: English
Weight: 530 KB
Volume: 33
Category: Article
ISSN: 0006-2952
DOI: 10.1016/0006-2952(84)90208-9

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## Abstract Orotate phosphoribosyl transferase (OPRT) is the main enzyme that involves in phosphoribosylation of 5‐fluorouracil (5‐FU), an essential step that leads to tumor growth inhibition. In our study, the prognostic relevance of OPRT, thymidylate synthase (TS) and dihydropyrimidine dehydrogen