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Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine

✍ Scribed by Gholamreza Sheikhnejad; Adam Brank; Judith K. Christman; Amanda Goddard; Estela Alvarez; Harry Ford Jr; Victor E. Marquez; Canio J. Marasco; Janice R. Sufrin; Margaret O’Gara; Xiaodong Cheng


Book ID
115629029
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
512 KB
Volume
285
Category
Article
ISSN
0022-2836

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A novel phosphoramidite (9) has been synthesized and shown to be an efficient coupling reagent for the synthesis ofoligonucleotide fragments containing the modified base 5,6-dihydro-5-azacytosine. With a model dihydro-5\_azacytosine/thymine dimer (z), oxidation of the dihydrotriazine ring to the aro