Mechanism of increased susceptibility to 4-nitroquinoline-1-oxide in cultured skin fibroblasts from patients with familial polyposis coli

Increased formation of unintegrated vira

Increased formation of unintegrated viral DNA in skin fibroblasts from patients with familial polyposis coli shortly after infection with kirsten murine sarcoma virus

✍ Michiko Miyaki; Kiyoko Tanaka; Chicko Sato; Noriko Akamatsu; Takeo Mori; Nobuo T 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 853 KB

## Skin fibroblasts from patients with familial polyposis coli (FPC) exhibit increased frequency of morphological transformation, anchorage-independent growth, and enhanced production of viral RNA and viral particles after infection with murine sarcoma virus(murine leukemia virus), MSV(MLV). These