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Mechanism of Homogeneous Iridium-Catalyzed Alkylation of Amines with Alcohols from a DFT Study

โœ Scribed by Balcells, David; Nova, Ainara; Clot, Eric; Gnanamgari, Dinakar; Crabtree, Robert H.; Eisenstein, Odile


Book ID
117997821
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
272 KB
Volume
27
Category
Article
ISSN
0276-7333

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N-Alkylation of amines with alcohols cat
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A new effective catalytic system consisting of [Cp\*IrCl 2 ] 2 /K 2 CO 3 (Cp\*=pentamethylcyclopentadienyl) for the N-alkylation of primary amines with alcohols has been developed. As an example, the reaction of aniline with benzyl alcohol in the presence of [Cp\*IrCl 2 ] 2 (5.0 mol%Ir) and K 2 CO 3