Mechanism of HIV protein induced modulation of mesenchymal stem cell osteogenic differentiation
โ Scribed by Eoin J Cotter; Herbert Shi Ming Ip; William G Powderly; Peter P Doran
- Book ID
- 115017342
- Publisher
- BioMed Central
- Year
- 2008
- Tongue
- English
- Weight
- 684 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1471-2474
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## Abstract There is a need to develop improved methods for directing and maintaining the differentiation of human mesenchymal stem cells (hMSC) for regenerative medicine. Here, we present a method for embedding cells in defined protein microenvironments for the directed osteogenic differentiation
Osteoclast activity has traditionally been regarded as restricted to bone resorption but there is some evidence that also non-resorbing osteoclasts might influence osteoblast activity. The aim of the present study was to further investigate the hypothesis of an anabolic function of non-resorbing ost