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Mechanism of HDAC inhibitor FR235222-mediated IL-2 transcriptional repression in Jurkat cells

✍ Scribed by Hideaki Matsuoka; Takao Fujimura; Hiroaki Mori; Ichiro Aramori; Seitaro Mutoh


Book ID
116576187
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
537 KB
Volume
7
Category
Article
ISSN
1567-5769

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ICER/CREM-mediated transcriptional atten
✍ Josef Bodor; Zoltan Fehervari; Betty Diamond; Shimon Sakaguchi πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 493 KB

## Abstract Here, we report that inducible cAMP early repressor/cAMP response element modulator (ICER/CREM) is induced early in CD25^+^CD4^+^ regulatory T cell (T~R~) assays mainly in activated Foxp3^–^ effector T cells and this induction correlates with sharp decrease in number of IL‐2‐expressing