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Mechanism of glutathione-mediated DNA damage by the antineoplastic agent 1,3-bis(2-chloroethyl)-N-nitrosourea

✍ Scribed by Stahl, Wilhelm; Lenhardt, Susanne; Przybylski, Michael; Eisenbrand, Gerhard


Book ID
126277129
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
495 KB
Volume
5
Category
Article
ISSN
0893-228X

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In a study designed to examine the nature of short-lived, electrophilic intermediates liberated during decomposition of N,N'-bis(2-chloroethyI)-N-nitrosourea (BCNU) in vitro and also on administration of BCNU (140 pmol i.p.) to rats in vivo, both on-line and off-line LC/MS/MS techniques were employe