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Mechanism of Destabilized RyR2 Channel in Catecholaminergic Polymorphic Ventricular Tachycardia

✍ Scribed by Takeshi Suetomi; Masafumi Yano; Masakazu Fukuda; Akihiro Hino; Xiaojuan Xu; Makoto Ono; Hitoshi Uchinoumi; Shigeki Kobayashi; Takeshi Yamamoto; Masunori Matsuzaki

Book ID
116340488
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
40 KB
Volume
16
Category
Article
ISSN
1532-8414

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## Abstract The cardiac ryanodine receptor (RyR2), the major calcium release channel on the sarcoplasmic reticulum (SR) in cardiomyocytes, has recently been shown to be involved in at least two forms of sudden cardiac death (SCD): (1) Catecholaminergic polymorphic ventricular tachycardia (CPVT) or