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Mechanism of cytochrome P-450 catalysis. Mechanism of N-dealkylation and amine oxide deoxygenation

✍ Scribed by Burka, Leo T.; Guengerich, F. Peter; Willard, Randolf J.; Macdonald, Timothy L.


Book ID
111685096
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
414 KB
Volume
107
Category
Article
ISSN
0002-7863

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Mechanisms of cytochrome P450 substrate
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## Abstract Cytochrome P450 (P450) enzymes catalyze a variety of oxidation and some reduction reactions, collectively involving thousands of substrates. A general chemical mechanism can be used to rationalize most of the oxidations and involves a perfenyl intermediate (FeO^3+^) and odd‐electron che