Mechanism of Co(salen)-catalyzed oxygenolysis of indole ring as a model for the tryptophan-2,3-dioxygenase reaction

✍ Scribed by A Nishinaga; H Ohara; H Tomita; T Matsuura

• Book ID: 104216893
• Publisher: Elsevier Science
• Year: 1983
• Tongue: French
• Weight: 246 KB
• Volume: 24
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)81368-4

✦ Synopsis

In the Co(Salen)-catalyzed oxygenolysis of 3-methylindole giving rise to o-formyl-_ aminoacetophenone, the actual active catalyst species has been found to be the Co(III)-(Salen) complex of an anion of the product. The catalysis involves activation of the substrate but not molecular oxygen. The activation of the substrate involves the rate determining proton transfer from the substrate to the product anion in the coordination sphere of the catalyst. The oxygenolysis of the heterocyclic ring of 3-substituted indoles related to tryptophan catalyzed by transition metal complexes such as Co(Salen),' CO(TPP),~ Mn(Pc),' and CUC~(PY)~ have been reported as chemical models for the tryptophan-2,3-dioxygenase reaction. With respect