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Mechanism of chloroform nephrotoxicity: IV. Phenobarbital potentiation of in vitro chloroform metabolism and toxicity in rabbit kidneys

โœ Scribed by Marc B. Bailie; Jacqueline H. Smith; John F. Newton; Jerry B. Hook


Book ID
113206310
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
719 KB
Volume
74
Category
Article
ISSN
0041-008X

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Chloroform is a non-genotoxic compound that is present in drinking water and ambient air as a result of water chlorination but whose carcinogenic mechanism in humans is unknown. Chloroform targets the liver in humans, where cytochrome P-450-dependent biotransformation to phosgene results in mitochon