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Mechanism of azathioprine-induced injury to hepatocytes: roles of glutathione depletion and mitochondrial injury

✍ Scribed by Alice U Lee; Geoffrey C Farrell

Book ID
119526710
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
550 KB
Volume
35
Category
Article
ISSN
0168-8278

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## Abstract Naphthalene is metabolized in the lung and liver to reactive intermediates by cytochrome P450 enzymes. These reactive species deplete glutathione, covalently bind to proteins, and cause necrosis in Clara cells of the lung. The importance of glutathione loss in naphthalene toxicity was i