Mechanism of arsenic-induced inhibition of erythropoiesis in mice

✍ Scribed by Bernard S. Morse; Maureen Conlan; Dennis G. Giuliani; Murray Nussbaum

• Publisher: John Wiley and Sons
• Year: 1980
• Tongue: English
• Weight: 391 KB
• Volume: 8
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/ajh.2830080305

✦ Synopsis

Abstract

Anemia accompanies arsenic intoxication in man. The present studies were undertaken to clarify further the effects of arsenic on erythropoiesis. A dose‐related inhibition of red cell ^59^Fe incorporation and reticulocyte response was observed in normal mice treated with a single injection of arsenic. Arsenite was approximately two times as inhibitory as arsenate. The effects of arsenic on erythropoietin‐induced erythroid differentiation revealed a significant inhibitory effect on young, proliferating marrow nucleated erythroid precursor cells. More mature, nonproliferating nucleated erythroid cells were resistant to the toxic action of arsenic. A dose‐related inhibitory effect of arsenic on DNA synthesis was observed in fetal liver nucleated erythroid cells incubated with ^3^H thymidine. Ineffective erythropoiesis as well as the megaloblastic morphology accompanying aberrant DNA synthesis – manifestations of arsenic toxicity in man – were not evident in the present studies.