Mechanism of apoptosis in HL-60 cells induced by n-3 and n-6 polyunsaturated fatty acids
✍ Scribed by Kayo Arita; Hirotsugu Kobuchi; Toshihiko Utsumi; Yoshiki Takehara; Jitsuo Akiyama; Alan A Horton; Kozo Utsumi
- Book ID
- 113992750
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 524 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0006-2952
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## Abstract As an extension of our recently published work (Mlejnek and Kuglík [2000] J. Cell. Biochem. 77:6–17), the role of caspases in N^6^‐benzylaminopurine riboside (BAPR)‐induced apotosis in HL‐60 cells was evaluated in this study. Here, BAPR‐induced apoptosis was accompanied by activation of
Treatment of HL-60 cells with micromolar concentrations of N 6 -benzyladenosine (N 6 -benzylaminopurine riboside [BAPR]) led to the occurrence of apoptosis in a concentration-dependent manner. Incubation period as short as 2 h in the presence of BAPR was sufficient for triggering irreversible change