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Mechanism of antiviral activity of triterpenoid saponins

✍ Scribed by Dr. C. M. O. Simões; M. Amoros; L. Girre

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 165 KB
Volume: 13
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199906)13:4<323::aid-ptr448>3.0.co;2-c

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✦ Synopsis

Triterpenoid saponins are naturally occurring sugar conjugates of triterpenes possessing various biological activities, including antiviral action. Two substances isolated from natural sources were tested against herpes simplex virus type 1 replication. They did not show evidence of cytotoxicity under antiviral test conditions. The triterpenoid saponin, isolated from a Brazilian plant (s21), represents the oleanane group and inhibited herpes simplex virus type 1 DNA synthesis. The triterpenoid saponin, isolated from a Chinese plant (s17), represents the ursane group and seemed to inhibit viral capsid protein synthesis of herpes simplex virus type 1.

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