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Mechanism of aminoacylation of tRNA. Proof of the aminoacyl adenylate pathway for the isoleucyl- and tyrosyl-tRNA synthetases from Escherichia coli K12

✍ Scribed by Fersht, Alan R.; Kaethner, Meredith M.

Book ID
120590762
Publisher
American Chemical Society
Year
1976
Tongue
English
Weight
676 KB
Volume
15
Category
Article
ISSN
0006-2960

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Spontaneous revertants of a temperature-sensitive Escherichia coli strain harboring a thermolabile leucyl-tRNA synthetase and seryl-tRNA synthetase were selected for growth at 40 degrees C. Among these, strains were found with increased levels of both thermolabile synthetases. Two distinct genetic l