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Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

✍ Scribed by Paul T.C Wan; Mathew J Garnett; S.Mark Roe; Sharlene Lee; Dan Niculescu-Duvaz; Valerie M Good; Cancer Genome Project; C.Michael Jones; Christopher J Marshall; Caroline J Springer; David Barford; Richard Marais


Book ID
117269853
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
806 KB
Volume
116
Category
Article
ISSN
0092-8674

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Activation of tissue-factor gene express
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Tissue factor (TF) is a cell-surface glycoprotein responsible for initiating the extrinsic pathway of coagulation. The overexpression of TF in human malignancy has been correlated with the angiogenic phenotype, poor prognosis, and thromboembolic complications. The mechanisms underlying constitutive