✦ LIBER ✦

Mechanism of action of verbascoside on the isolated rat heart: increases in level of prostacyclin

✍ Scribed by M. Pennacchio; Y. M. Syah; E. Alexander; E. L. Ghisalberti

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 36 KB
Volume: 13
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199905)13:3<254::aid-ptr430>3.0.co;2-1

No coin nor oath required. For personal study only.

✦ Synopsis

The mechanism of the positive cardioactive effects induced by verbascoside in the Lagendorff rat heart has been investigated. Isolated rat hearts treated with aor badrenergic agents did not show significant reduction of the positive chronotropism, inotropism and increased coronary perfusion rate mediated by verbascoside. A significant increase in prostacyclin levels (142%) observed following the administration of verbascoside suggests that prostacyclin stimulates formation of cAMP which induces the cardioactivity associated with verbascoside.

📜 SIMILAR VOLUMES

The effect of increased lipoprotein leve

The effect of increased lipoprotein levels on the pharmacokinetics of cyclosporine A in the laboratory rat

✍ Dion R. Brocks; Shahram Ala; Hamidreza Montazeri Aliabadi 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 157 KB 👁 2 views

## Abstract The response of cyclosporine A (CyA) blood concentrations following changes in lipoprotein levels have been inconsistent. Some studies show increases in concentrations, whereas others have shown decreases. The intent of this study was to examine the effect of two rat models of increased

Acute effect of antidiabetic 1,4-dihydro

Acute effect of antidiabetic 1,4-dihydropyridine compound cerebrocrast on cardiac function and glucose metabolism in the isolated, perfused normal rat heart

✍ Janina Briede; Mara Stivrina; Brigita Vigante; Dzintra Stoldere; Gunars Duburs 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 137 KB 👁 1 views