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Mechanism of action of coenzyme B12. Quantum-chemical considerations

✍ Scribed by Ingrid I. Merkelbach; Henk M. Buck


Book ID
104588228
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
326 KB
Volume
99
Category
Article
ISSN
0165-0513

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✦ Synopsis


Abstract

Quantum‐chemical calculations are carried out on simplified models to obtain insight in the mechanistic aspects of coenzyme B~12~


πŸ“œ SIMILAR VOLUMES


Ethanolamine ammonia-lyase: Inactivation
✍ G.N. Schrauzer; E.A. Stadlbauer πŸ“‚ Article πŸ“… 1975 πŸ› Elsevier Science βš– 787 KB

Functional ethanolamine ammonia-lyase is inactivated by N1O as well as by 0 +, indicating that the active form of coenzyme B, Z is an enzyme-bound corrin derivative in which the Co-C bond of the coenzyme is broken and the cobalt ion is in the +l state of oxidation. The nucleoside fragment formed in