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Mechanism of action of anticancer drugs at a cellular level

✍ Scribed by David A. Karnofsky

Book ID
115067046
Publisher
American Cancer Society
Year
1968
Tongue
English
Weight
279 KB
Volume
18
Category
Article
ISSN
0007-9235

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## Abstract The tumor‐associated carbonic anhydrase (CA, EC 4.2.1.1) isozyme CA IX is highly overexpressed in many cancer types via the hypoxia inducible factor‐1Ξ± (HIF‐1Ξ±) cascade. Hypoxic tumors expressing CA IX show a poor response to classical chemo‐ and radio‐therapy treatments. CA IX signific