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Mechanism of action of 1,25-dihydroxyvitamin D3on intestinal calcium absorption

✍ Scribed by Sylvia Christakos

Publisher
Springer
Year
2011
Tongue
English
Weight
186 KB
Volume
13
Category
Article
ISSN
1389-9155

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An intestinal perfusion technique is reported for the study of the differential absorption of vitamin D3 and its active metabolite, 1,25dihydroxyvitamin D3, through intact jejunal segments of rats. Samples of introduced and collected perfusates, intestinal homogenates, and portal blood were assayed

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## Abstract The steroid hormone 1,25‐dihydroxyvitamin D~3~ [1,25(OH)~2~D~3~] rapidly stimulates the uptake of phosphate in isolated chick intestinal cells, while the steroid 24,25‐dihydroxyvitamin D~3~ [24,25(OH)~2~D~3~] inhibits the rapid stimulation by 1,25(OH)~2~D~3~. Earlier work in this labora