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Mechanism of action and spectrum of cell types susceptible to doxorubicin photochemotherapy

โœ Scribed by Jian-Ping Gao; Karl W. Lanks; M. Rosen; Bai-Tang Lai

Book ID
105994208
Publisher
Springer
Year
1997
Tongue
English
Weight
164 KB
Volume
40
Category
Article
ISSN
0344-5704

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## Abstract Inactivation of poly(ADPโ€ribose) polymeraseโ€1 (PARPโ€1) has been shown to potentiate the cytotoxicity of distinct DNA targeting agents including topoisomerase I inhibitors. On the other hand, the PARPโ€1 deficient cells exhibited resistance to conventional inhibitors of topoisomerase II s