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Mechanism of abnormal growth in astrocytes derived from a mouse model of GM2 gangliosidosis

✍ Scribed by Nagako Kawashima; Daisuke Tsuji; Tetsuya Okuda; Kohji Itoh; Ken-ichi Nakayama

Book ID: 111183693
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 563 KB
Volume: 111
Category: Article
ISSN: 0022-3042
DOI: 10.1111/j.1471-4159.2009.06391.x

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## Abstract Niemann‐Pick disease type C (NPC) is a deadly neurodegenerative disease often caused by mutation in a gene called NPC1, which results in the accumulation of unesterified cholesterol and glycosphingolipids in the endosomal–lysosomal system. Most studies on the mechanisms of neurodegenera