✦ LIBER ✦
Mechanism insights into an unexpected isomerisation reaction observed during conversion of N-benzyl piperazinones to corresponding N-benzyl thio-piperazinones
✍ Scribed by Emanuele Miserazzi; Mario Alessandro Spotti; Roberto Profeta; Simone Spada; Arnaldo Nalin; Elisa Moro; Daniele Andreotti
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 693 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
An interesting and surprising rearrangement was observed during the reaction of 4-N-benzyl piperazinone derivatives with Lawesson's reagent as a thionating agent. Investigation into the possible mechanism responsible for these results is reported herein.