𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling of Bidirectional Effect of Danshensu on Plasma Homocysteine in Rats

✍ Scribed by Yuancheng Chen; Yanguang Cao; Jia Zhou; Xiaoquan Liu


Publisher
Springer US
Year
2009
Tongue
English
Weight
243 KB
Volume
26
Category
Article
ISSN
0724-8741

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Pharmacokinetic/pharmacodynamic modeling
✍ Ryan J. Hansen; Joseph P. Balthasar 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 143 KB

Recently, our laboratory reported that intravenous immunoglobulin (IVIG) treatment increased antiplatelet antibody (7E3) clearance in a rat model of immune thrombocytopenic purpura (ITP). However, due to the multifaceted nature of IVIG therapy, the contribution of this increase in antiplatelet antib

Influence of plasma protein binding on p
✍ T.J. van Steeg; V.B. Boralli; E.H.J. Krekels; P. Slijkerman; J. Freijer; M. Danh 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 205 KB

The objective of this investigation was to examine in a systematic manner the influence of plasma protein binding on in vivo pharmacodynamics. Comparative pharmacokinetic-pharmacodynamic studies with four b blockers were performed in conscious rats, using heart rate under isoprenaline-induced tachyc

Effect of altered AGP plasma binding on
✍ T.J. van Steeg; E.H.J. Krekels; J. Freijer; M. Danhof; E.C.M. de Lange 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB

In contrast to the impact of plasma protein binding on pharmacokinetics, no quantitative in vivo information is available on its impact on pharmacodynamics. The pharmacokinetic-pharmacodynamic relationship of the model drug S(À)-propranolol was evaluated using mechanism-based estimations of in vivo