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Mechanism and synthesis of pharmacologically active quinolones from Morita–Baylis–Hillman adducts

✍ Scribed by Giovanni W. Amarante; Mario Benassi; Robert N. Pascoal; Marcos N. Eberlin; Fernando Coelho


Book ID
118501451
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
727 KB
Volume
66
Category
Article
ISSN
0040-4020

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Acyloins from Morita–Baylis–Hillman addu
✍ Giovanni W. Amarante; Patrícia Rezende; Mayra Cavallaro; Fernando Coelho 📂 Article 📅 2008 🏛 Elsevier Science 🌐 French ⚖ 137 KB

In this Letter, we describe an easy and straightforward strategy for the preparation of acyloins (a-hydroxyketones) from Morita-Baylis-Hillman adducts, based on a Curtius rearrangement. Different acyloins were obtained with good overall yield (>40% for three steps). To exemplify the synthetic useful