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Mechanism and function of heat shock-dependent IκBα expression

✍ Scribed by K. E. Dunsmore; A. G. Denenberg; K. Page; H. R. Wong


Book ID
105752822
Publisher
SP Birkhäuser Verlag Basel
Year
2006
Tongue
English
Weight
143 KB
Volume
55
Category
Article
ISSN
1420-908X

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Arsenite stabilizes IκBα and prevents NF
✍ Dan D. Hershko; Bruce W. Robb; Eric S. Hungness; Guangju Luo; Per-Olof Hasselgre 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 229 KB

## Abstract Recent studies suggest that sodium arsenite downregulates NF‐κB activity by inhibiting phosphorylation and subsequent degradation of IκBα. Many effects of sodium arsenite are secondary to induction of heat shock proteins. The role of the heat shock response in arsenite‐induced inhibitio