Mechanics of the Circulation

✍ Scribed by Hugh E. Huxley (auth.), H. E. D. J. Ter Keurs MD, PhD, J. V. Tyberg MD, PhD (eds.)

• Publisher: Springer Netherlands
• Year: 1987
• Tongue: English
• Leaves: 277
• Series: Developments in Cardiovascular Medicine 69
• Edition: 1
• Category: Library

✦ Synopsis

This volume constitutes the proceedings of a satellite symposium of the XXXth congress of the International Union of Physiological Sciences. The symposium has been held In Banff, Alberta Canada July 9-11 1986. The program was organized to provide a selective overview of current developments in cardiac biophysics, biochemistry, and physiology. In order to highlight areas of develop­ ing ideas and to stimulate the participants' inquisitiveness into the nature and complexity of the integrated cardiovascular system, lectures and discussions were presented that emphasized evolving and sometimes provocative concepts in the field. With the same goal in mind we have, for the readers of this volume, briefly summarized the general discussions. We would like to thank several individuals whose dedication made this sym­ posium and publication of the proceedings possible. Mrs. Lois Kokoski and Mrs. Madeleine Aldridge of the Conference Office of the University of Calgary seemingly effortlessly handled the details of the symposium. Peter de Tombe, Dr. Peter Backx and Dr. Jeroen Bucx transcribed the general discussions. Finally, we appreciate the extra effort of our secretaries, Lenore Doell and Gregory Douglas, and the work of Anna Tyberg who prepared the final manuscripts for publication. Henk E.D.J. ter Keurs, M.D. Ph.D. John V. Tyberg, M.D. Ph.D.

✦ Table of Contents

Front Matter....Pages I-IX
How do crossbridges produce the sliding force between actin and myosin filaments in muscle....Pages 1-13
Stepwise shortening and the mechanism of contraction....Pages 15-35
Mechanics of the myofibril....Pages 37-49
Excitation-contraction coupling in myocardium: implications of calcium release and Na/Ca exchange....Pages 51-60
Calcium influx and sarcoplasmic reticulum calcium release in cardiac excitation-contraction coupling....Pages 61-68
Cardiac energetics....Pages 69-86
Energetics of the heart....Pages 87-89
On the force-length relation in myocardium....Pages 91-105
Segment length mechanics of cardiac muscle; force, velocity and stiffness in cardiac muscle vary with length and calcium....Pages 107-111
Regulation of the actin-myosin interaction by calcium; the troponin tropomyosin complex....Pages 113-130
Evidence that a decrease in sarcomere length reduces the Ca ++ affinity of troponin in the intact cardiac myofibril....Pages 131-133
Mechanics of cardiac contraction and the phosphorylation of sarcotubular and myofilament proteins....Pages 135-152
Ventricular pump function and arterial resistance....Pages 153-163
Ventricular wall motion....Pages 165-169
Mechanics of the ventricular septum....Pages 171-188
Mechanics of the interventricular septum....Pages 189-194
On the interaction between the pericardium and the heart....Pages 195-206
The mechanical effects of the pericardium on the left ventricle....Pages 207-211
Role of a changing venous capacitance in cardiovascular homeostasis....Pages 213-225
Role of a changing venous capacitance in cardiovascular homeostasis....Pages 227-231
Principles of arterial hemodynamics....Pages 233-259
Arterial dynamics: a comment on arterial wave reflections....Pages 261-264
Control of the circulation....Pages 265-278
Back Matter....Pages 279-281

✦ Subjects

Cardiology; Hematology