The effects of parathyroid hormone (PTH) on 1,4,5-inositol triphosphate (1,4,5-IP 3 ) and intracellular free calcium (Ca i 21 ) in osteoblasts are variable, whereas adenylate cyclase activity is consistently stimulated. Cyclic AMP is considered a mediator in the contractile effects of PTH on osteobl
Mechanically induced intracellular calcium waves in osteoblasts demonstrate calcium fingerprints in bone cell mechanotransduction
โ Scribed by Lindsay M. Godin; Sakiko Suzuki; Christopher R. Jacobs; Henry J. Donahue; Seth W. Donahue
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- English
- Weight
- 294 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1617-7959
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The present study was designed to characterize the cross-talk of parathyroid hormone (PTH)-responsive dual signal transduction systems (CAMP-dependent protein kinase (PKA) and calcium/protein kinase C [PKCI) and its participation in PTH-induced homologous desensitization of intracellular calcium ([C
Phytate (inositol hexa-phosphate, IP6) possesses multiple biological functions including anticancer activity. IP6 is converted to inositol di-, tri-, and tetra-phosphates (IP2, IP3, and IP4) by phytase in large intestinal microbes; however, their contribution to the IP6-mediated functions has not be