Mechanical stretch induces TGF-β synthesis in hepatic stellate cells
✍ Scribed by R. Sakata; T. Ueno; T. Nakamura; H. Ueno; M. Sata
- Book ID
- 108711041
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 190 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0014-2972
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Transforming growth factor (TGF)-beta is critically involved in the activation of hepatic stellate cells (HSCs) that occurs during the process of liver damage, for example, by alcohol, hepatotoxic viruses, or aflatoxins. Overexpression of the TGF-beta antagonist Smad7 inhibits transdifferentiation a
## Abstract The development of hepatocellular carcinomas from malignant hepatocytes is frequently associated with intra‐ and peritumoral accumulation of connective tissue arising from activated hepatic stellate cells. For both tumorigenesis and hepatic fibrogenesis, transforming growth factor (TGF)