𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Mechanical stresses and endochondral ossification in the chondroepiphysis

✍ Scribed by Dr. Dennis R. Carter; Marcy Wong


Book ID
102913800
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
828 KB
Volume
6
Category
Article
ISSN
0736-0266

No coin nor oath required. For personal study only.

✦ Synopsis


In 191 1 , Gebhardt used a photoelastic model to relate mechanical stresses to the ossification pattern of the chondroepiphysis. Pauwels later conducted a photoelastic study using the same model geometry to develop a theory that the secondary ossific nucleus originates at a position of high-magnitude hydrostatic pressure where the shear stresses are zero. We conducted two-dimensional finite element analyses of the model used by Gebhardt and Pauwels. We demonstrate that Pauwels's photoelastic results are correct but are based on the imposition of incorrect boundary conditions. When more realistic boundary conditions were used, the finite element results changed dramatically. These results suggest that (a) the ossific nucleus appears in an area of high shear (deviatoric) stresses; (b) the edge of the advancing ossification front (zone of Ranvier or ossification grove) also experiences high shear stresses; and (c) the joint surface, where articular cartilage forms, is exposed to high-magnitude hydrostatic compression. These findings support the theory proposed by Carter and associates that intermittently applied shear stresses (or strain energy) promote endochondral ossification and that intermittently applied hydrostatic compression inhibits or prevents cartilage degeneration and ossification.


πŸ“œ SIMILAR VOLUMES


The role of morphogens in endochondral o
✍ John T. Campbell; Frederick S. Kaplan πŸ“‚ Article πŸ“… 1992 πŸ› Springer 🌐 English βš– 909 KB

The formation of bone occurs normally by one of two developmental processes: intramembranous or endochondral ossification. Endochondral ossification occurs in the morphogenesis of the limb buds and growth plates, and in the regeneration of bone following injury (fracture callus). Two classes of diff

Active role of chondrocyte apoptosis in
✍ Gibson, Gary πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 566 KB

Endochondral ossification involves an ordered progression from cell division through hypertrophic differentiation to cell death. The apoptotic nature of chondrocyte death was first suggested by characteristic changes in morphology; and more recently by the pattern of DNA fragmentation and other char

Does static precede dynamic osteogenesis
✍ Ferretti, Marzia ;Palumbo, Carla ;Bertoni, Laura ;Cavani, Francesco ;Marotti, Ga πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 512 KB

## Abstract Endochondral ossification takes place with calcified cartilage cores providing a rigid scaffold for new bone formation. Intramembranous ossification begins in connective tissue and new bone formed by a process of static ossification (SO) followed by dynamic ossification (DO) as previous