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Mechanical Characterization of Motor Proteins: A Molecular Dynamics Approach

✍ Scribed by Iuliana Aprodu; Monica Soncini; Alberto Redaelli

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 500 KB
Volume: 17
Category: Article
ISSN: 1022-1344
DOI: 10.1002/mats.200800033

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✦ Synopsis

Abstract

A new approach, based on molecular dynamics, is presented to measure the mechanical properties of motor proteins, which are important for accomplishing their intracellular functions. Two different set‐ups were designed to mimic the optical tweezers and surface force apparatus experiments. The results obtained show that the stiffness and elastic modulus of kinesin motor domain are 377 pN · nm^−1^ and 0.17 GPa, respectively, while the myosin motor domain is characterized by a stiffness of 271 pN · nm^−1^ and an elastic modulus of 0.26 GPa. These results suggest that the source of the very low stiffness detected for full‐length molecules is located outside of the globular part of the proteins.

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