Numerous studies suggest that age-related declines in memory storage are related to impairment of central cholinergic systems. Scopolamine, a muscarinic cholinergic antagonist, has been used with young humans and other animal species as a model of the cognitive impairment that often accompanies norm
Mecamylamine reverses physostigmine-induced attenuation of scopolamine-induced hyperactivity
✍ Scribed by M. F. O'Neill; A. G. Fernández; R. W. Gristwood; J. M. Palacios
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 692 KB
- Volume
- 96
- Category
- Article
- ISSN
- 1435-1463
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In a series of five experiments, the modulating role of naloxone on a scopolamine-induced retention deficit in a passive avoidance paradigm was investigated in mice. Scopolamine, but not methyl scopolamine (1 and 3 mg/kg), induced an amnesia as measured by latency and duration parameters. Naloxone (