Heterocyclic amines (HAs) are carcinogens produced by high-temperature cooking of meat and animal protein; metabolism of HA is influenced by polymorphisms in the Nacetyltransferase-2 (NAT-2) gene. Data from a variety of sources suggest that HA may play a role in human carcinogenesis. We examined the
Meat, fish and egg intake and risk of breast cancer
โ Scribed by Michelle D. Holmes; Graham A. Colditz; David J. Hunter; Susan E. Hankinson; Bernard Rosner; Frank E. Speizer; Walter C. Willett
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- French
- Weight
- 216 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0020-7136
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โฆ Synopsis
Abstract
Intakes of animal protein, meat, and eggs have been associated with breast cancer incidence and mortality in ecological studies, but data from longโterm prospective studies are limited. We therefore examined these relationships in the Nurses' Health Study. We followed 88,647 women for 18 years, with 5 assessments of diet by food frequency questionnaire, cumulatively averaged and updated over time. We calculated the relative risks (RR) and 95% confidence intervals (95% CI) for risk of developing invasive breast cancer, over categories of nutrient and food intake. During followโup, 4,107 women developed invasive breast cancer. Compared to the lowest quintile of intake, the RR and 95% CI for the highest quintile of intake were 1.02 (0.92โ1.14) for animal protein, 0.93 (0.83โ1.05) for red meat and 0.89 (0.79โ1.00) for all meat. Results did not differ by menopausal status or family history of breast cancer. We found no evidence that intake of meat or fish during midโlife and later was associated with risk of breast cancer. ยฉ 2003 WileyโLiss, Inc.
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