Measuring the rate of intramolecular contact formation in polypeptides
โ Scribed by Lapidus, L. J.; Eaton, W. A.; Hofrichter, J.
- Book ID
- 121740925
- Publisher
- National Academy of Sciences
- Year
- 2000
- Tongue
- English
- Weight
- 145 KB
- Volume
- 97
- Category
- Article
- ISSN
- 0027-8424
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๐ SIMILAR VOLUMES
An explanation is suggested for why a marginally stable beta-structure folds extremely slowly; it is predicted that even a small increase in stability drastically accelerates beta-folding. According to the theory, this folding is a first-order phase transition, and the rate-limiting step is nucleati
The folded nature of an intramolecular antiparallel 8-sheet suggests that the introduction of this structure into a statistical coil might be accompanied by a contraction of the chain. The magnitude of the contraction, and the conditions that produce the maximum contraction, have been assessed by th