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Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma

✍ Scribed by Peters, Michael C.; Mekonnen, Zesemayat K.; Yuan, Shaopeng; Bhakta, Nirav R.; Woodruff, Prescott G.; Fahy, John V.


Book ID
121288053
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
933 KB
Volume
133
Category
Article
ISSN
1097-6825

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The T1/ST2 gene encodes, as a result of differential splicing, a cell surface protein (transmembrane form of T1/ST2, ST2L) and a soluble, secreted, protein (ST2). Here, we show that transcripts for both ST2L and ST2 are present in activated human Th2 clones, but not in Th1 and T regulatory clones. T