Measurement of the urinary metabolites of n-hexane, cyclohexane and their isomers by gas chromatography

✍ Scribed by L. Perbellini; F. Brugnone; R. Silvestri; E. Gaffuri

• Book ID: 104760387
• Publisher: Springer-Verlag
• Year: 1981
• Tongue: English
• Weight: 477 KB
• Volume: 48
• Category: Article
• ISSN: 0340-0131
• DOI: 10.1007/bf00405936

✦ Synopsis

A gas chromatographic method for analyzing the urinary metabolites of n-hexane ( 2-hexanol, 2,5-hexanedione, 2,5-dimethylfuran and y-valerolactone), of 2-methylpentane ( 2-methyl-2-pentanol), of 3-methylpentane ( 3methyl-2-pentanol), and of cyclohexane (cyclohexanol) was developed Processing of urine and the gas chromatographic conditions are described The recovery rate of all hexane metabolites, except 2,5-dimethylfuran, ranged between 92 and 100 % The variation coefficient of metabolites determination was between 1 5 and 5 %, apart from 2,5-dimethylfuran determination for which the variation coefficient was 15 % The detection limits ranged between 0.2 and 0 7 mg/1 and between 0 05 and 0 1 mg/l when a packed or capillary column was used Results obtained from a packed and capillary column are discussed.