Measurement of T1 relaxation times of cardiac phosphate metabolites using BIR-4 adiabatic RF pulses and a variable nutation method
✍ Scribed by Hajime Sakuma; Sarah J. Nelson; Daniel B. Vigneron; Jaakko Hartiala; Charles B. Higgins
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 342 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
T~1~relaxation times of PCr and β‐ATP in human cardiac and skeletal muscle were evaluated using a variable nutation method. This allows T~1~measurements with a constant TR and a significant reduction in acquisition time compared with the partial saturation method. Four 1D CSI datasets were obtained using 30°, 45°, 60°, and 90° BIR‐4 adiabatic RF pulses within 40 min. The T~1~of the phosphate phantom obtained with this method agreed with values obtained with the partial saturation method. The T~1~s of PCr and β‐ATP in heart are 3.98 = 0.18 s and 1.86 ± 0.16 s (mean = SE). Our results demonstrated that T~1~ values in heart and skeletal muscle are not significantly different.