Measurement of specific radioactivity of tryptophan labeled with carbon-14 in plasma by high-performance liquid chromatograph with a synchronized accumulating radioisotope detector

✍ Scribed by Shigeo Baba; Jun-ichi Yamaguchi; Masanobu Horie

• Publisher: Elsevier Science
• Year: 1988
• Tongue: English
• Weight: 449 KB
• Volume: 173
• Category: Article
• ISSN: 0003-2697
• DOI: 10.1016/0003-2697(88)90177-7

✦ Synopsis

Measurement of specific radioactivity by a high-performance liquid chromatograph with a synchronized accumulating radioisotope detector was conducted. Accuracy of measurement for an authentic sample containing 0.2 nCi of tryptophan labeled with carbon-14 exceeded 95%. In the case of a plasma sample obtained 120 min following intravenous administration of 15 pCi of labeled tryptophan to a rat, the coefficient of variation was 7.0%.