𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Measurement of serum levels of des-γ-carboxy prothrombin in patients with hepatocellular carcinoma by a revised enzyme immunoassay kit with increased sensitivity

✍ Scribed by Hiroaki Okuda; Toshimi Nakanishi; Kazuko Takatsu; Akiko Saito; Naoaki Hayashi; Keisuke Watanabe; Naoki Magario; Takeshi Yokoo; Toru Naraki

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
100 KB
Volume
85
Category
Article
ISSN
0008-543X

No coin nor oath required. For personal study only.

✦ Synopsis

BACKGROUND.

Des-␥-carboxy prothrombin (DCP) is a useful tumor marker for hepatocellular carcinoma (HCC). The conventional enzyme immunoassay (EIA) kit for DCP lacks adequate sensitivity to detect small HCC. Thus, a revised EIA kit for DCP has been developed. In this revised DCP kit, the blank value has been reduced, making it now possible to obtain a normal value. The authors used this revised EIA kit for DCP with increased sensitivity and evaluated its usefulness as a tumor marker for HCC.

METHODS.

Serum DCP and ␣-fetoprotein (AFP) levels were determined in 60 patients with HCC, 60 with cirrhosis, 57 with chronic hepatitis, and 273 normal subjects. The cutoff value for the revised DCP kit was determined to be 40 mAU/ mL, and the values for the conventional DCP kit and AFP were 100 mAU/mL (0.1 AU/mL) and 20 ng/mL, respectively.

📜 SIMILAR VOLUMES

Serum levels of des-γ-carboxy prothrombi
Serum levels of des-γ-carboxy prothrombin measured using the revised enzyme immunoassay kit with increased sensitivity in relation to clinicopathologic features of solitary hepatocellular carcinoma
✍ Hiroaki Okuda; Toshimi Nakanishi; Kazuko Takatsu; Akiko Saito; Naoaki Hayashi; K 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 74 KB

## BACKGROUND. Des-␥-carboxy prothrombin (DCP) is an established marker for hepatocellular carcinoma (HCC), but the conventional enzyme immunoassay (EIA) kit lacks adequate sensitivity. Thus, a revised EIA kit with increased sensitivity has been developed. In this kit, the sensitivity has increased

The usefulness of determining des-γ-carb
The usefulness of determining des-γ-carboxy prothrombin by sensitive enzyme immunoassay in the early diagnosis of patients with hepatocellular carcinoma
✍ Yuhsaku Mita; Yutaka Aoyagi; Masahiko Yanagi; Takeshi Suda; Yasufumi Suzuki; Hit 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 87 KB 👁 1 views

## Background: Measurements of serum concentrations of des-gamma-carboxy prothrombin (dcp) are widely used for diagnosing hepatocellular carcinoma (hcc). however, the dcp is not always sensitive enough to detect small hccs. in the current study, the authors investigated the usefulness of dcp in the