Measurement of phosphorus content in normal and osteomalacic rabbit bone by solid-state 3D radial imaging
✍ Scribed by S. Anumula; J. Magland; S.L. Wehrli; H. Zhang; H. Ong; H.K. Song; F.W. Wehrli
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 537 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
In osteomalacia decreased mineralization reduces the stiffness and static strength of bone. We hypothesized that hypomineralization in osteomalacic bone could be quantified by solid‐state ^31^P magnetic resonance imaging (SS‐MRI). Hypomineralization was measured with a 3D radial imaging technique at 162 MHz (9.4T) in rabbit cortical bone of hypophosphatemic (HY) and normophosphatemic (NO) animals. The results were compared with those obtained by quantitative micro‐CT (μ‐CT) and ^31^P solution NMR. 3D images of 277 μm isotropic voxel size were obtained in 1.7 hr with SNR ∼ 9. Mineral content was lower in the HY relative to the NO group (SS‐MRI: 9.48 ± 0.4 vs. 11.15 ± 0.31 phosphorus wet wt %, P < 0.0001; μ‐CT: 1114.6 ± 28.3 vs. 1175.7 ± 23.5 mg mineral/cm^3^; P = 0.003). T~1~ was shorter in the HY group (47.2 ± 3.5 vs. 54.1 ± 2.7 s, P = 0.004), which suggests that relaxation occurs via a dipole‐dipole (DD) mechanism involving exchangeable water protons, which are more prevalent in bone from osteomalacic animals. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.