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Measurement of Oxidative DNA Damage by Catechol Estrogens and Analogues in Vitro

โœ Scribed by Mobley, James A.; Bhat, Abhijit S.; Brueggemeier, Robert W.


Book ID
126305887
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
124 KB
Volume
12
Category
Article
ISSN
0893-228X

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We compared the potential of asbestos and man-made fibers to attack DNA by the determination of the yield of 8-hydroxy-2'-deoxyguanosine (8-OH-dGuo) under several in vitro conditions. Asbestos induced 6.6-99.8 of 8-OH-dGuo per 10(5) dGuo in calf thymus DNA after 20 h of incubation, while the levels