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Measurement of osteoclasts and bone resorption by automated image analysis

✍ Scribed by Colin R. Dunstan; Peter D. Lauren; Nicole M. Somers; Richard A. Evans

Book ID
112119031
Publisher
American Society for Bone and Mineral Research
Year
2009
Tongue
English
Weight
544 KB
Volume
8
Category
Article
ISSN
0884-0431

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## Abstract We confirmed the expression of cathepsin K, the most abundant and specific cysteine protease found in osteoclasts, at the mRNA level in most of our cases of breast cancer, and even at the protein level in bone metastatic lesions. Therefore, we investigated the functions of cathepsin K i