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Measurement of nonlinear pO2 decay in mouse lungs using 3He-MRI

✍ Scribed by Katarzyna Cieślar; Hasan Alsaid; Vasile Stupar; Sophie Gaillard; Emmanuelle Canet-Soulas; Rachida Fissoune; Yannick Crémillieux

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
262 KB
Volume
20
Category
Article
ISSN
0952-3480

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✦ Synopsis

Abstract

Spatial and temporal variations in oxygen partial pressure (__p__O~2~) during breath‐hold can be exploited to obtain important regional parameters of lung function. In the course of apnea, the oxygen concentration is known to decay exponentially. Therefore, the initial __p__O~2~ (p~0~) can be used to represent local ventilation, and the oxygen depletion time constant can characterize perfusion. The protocol, based on a nonlinear model of __p__O~2~ decay, was validated in six healthy mice. Parametric maps of p~0~ and oxygen depletion time constant were obtained for pure ^3^He and ^3^He/air mixture. The mean measured values of p~0~ were 77 ± 9 mbar for the pure ^3^He insufflation and 107 ± 5 mbar for ^3^He/air mixture, in agreement with the predefined p~0~ values: 75 ± 15 mbar and 123 ± 15 mbar, respectively. The mean measured oxygen depletion time constants were 6.5 ± 0.2 s for pure ^3^He and 7.1 ± 0.8 s for the ^3^He/air mixture, in agreement with physiology. Copyright © 2007 John Wiley & Sons, Ltd.

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