Measurement of Mitochondrial Function in Human Platelets
β Scribed by Nayra Cardenes; Lisa Geary; Shilpa Jain; Catherine Corey; Christelle Kamga; Enrico M. Novelli; Suchitra Barge; Sruti Shiva
- Book ID
- 113632183
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 56 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0891-5849
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π SIMILAR VOLUMES
To measure the concentrations of cytosolic ionized calcium in platelets we used a calcium-sensitive fluorophor (Fura-2) with two different spectrofluorometers (Perkin-Elmer LS-5 and Fluorolog 222). Values obtained by these two instruments for the basal cytosolic ionized calcium concentration of rest
## Abstract Reports on mitochondrial respiratory chain (MRC) complex I (CI) dysfunction in the substantia nigra in Parkinson's disease (PD) support the oxidative stress hypothesis in the neuropathogenesis of PD. Studies in peripheral tissue have found variable decreased CI and occasionally other co