Measurement of intravascular Na+ during increased CBF using 23Na NMR with a shift reagent
✍ Scribed by Itamar Ronen; Seong-Gi Kim
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 103 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0952-3480
- DOI
- 10.1002/nbm.736
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✦ Synopsis
Abstract
Sodium ions are intimately involved with neural activity. Thus, it is highly desirable to devise a way of mapping brain activity via sodium imaging. Sodium ions exist in the extravascular and intravascular spaces. To separate the two components, the shift reagent Tm(DOTP)^5−^ was intravenously introduced into rats. Intravascular sodium changes in the rat brain were measured during increased blood flow induced by hypercapnia using volume‐localized ^23^Na‐NMR. The intravascular sodium changes, equivalent to cerebral blood volume changes, are significant during hypercapnia conditions and correlate well with the increase in arterial pCO~2~. This suggests that the intravascular sodium change is dominant in total ^23^Na spectroscopy or imaging of the brain during blood flow increase induced by external perturbation. Copyright © 2001 John Wiley & Sons, Ltd.